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- Building upon the gene-chromosome theory of heredity that originated with Gregor Mendel (1822–1884), August Weismann (1834–1914) proved that inheritance only takes place through gametes. No other cells can pass on inherited characters. The work of Katherine Esau (1898–1997) on plant anatomy is still a major foundation of modern botany.
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- Measuring single-cell genomes at scale in tissues and cell populations will greatly advance clonal decomposition of malignant tissues, studying properties of negative selection, resolving rare cell population genotypes and identifying DNA replication states of individual cells, all of which are hard to measure when cellular information is destroyed in bulk sequencing.
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